Denzel Washington Lincoln Rhyme Angelina Jolie Amelia Donaghy Queen Latifah Thelma Michael Rooker Captain Howard Cheney Michael McGlone Detective Kenny Solomon Luis Guzmán Eddie Ortiz Leland Orser Richard Thompson John Benjamin Hickey Dr. Barry Lehman Bobby Cannavale Steve, Amelia's Boyfriend Ed O'Neill Detective Paulie Sellitto Richard Zeman Lieutenant Carl Hanson Olivia Birkelund Lindsay Rubin Gary Swanson Alan Rubin Frank Fontaine Grandfather Zena Grey Granddaughter Desmond Campbell Taxi Inspector Peter Michael Dillon Homicide Detective Ted Whittall Ortiz's Assistant Andy Bradshaw Uniform Cop Steve Adams Gas Worker Larry Day Gas Worker Terry Simpson Cop in Apartment Eric Davis Cop in Apartment Arthur Holden Bookstore Clerk Yahsmin Daviault Rhyme's Sister David Warshofsky Amelia's Partner Mateo Gómez Hot Dog Vendor Fulvio Cecere Forensics Expert Russell Yuen Forensics Worker